Analysis of disease progression in patients with transthyretin cardiac amyloidosis
نویسندگان
چکیده
Background In transthyretin (TTR) cardiac amyloidosis, myocardial deposition of liver-derived TTR fibrils results in heart failure and death. Wild-type TTR (ATTRwt) amyloidosis is an acquired disease, whereas familial amyloidotic cardiomyopathy (FAC) is a hereditary form of the disease caused by mutations in the TTR gene resulting in the deposition of both mutant and wild-type TTR. Published data on disease progression in TTR cardiac amyloidosis is limited. To explore this further, we analyzed natural history data in ATTRwt amyloidosis patients to characterize disease progression in this population and compared this to our previously reported data in FAC.
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